Targeting interleukin-11 receptor in leukemia and lymphoma: A functional ligand-directed study and hematopathology analysis of patient-derived specimens
نویسندگان
چکیده
Department of Experimental Therapeutics, Department of Hematopathology, and Department of Genomic Medicine, Department of Cancer Systems Imaging, Department of Genitourinary Medical Oncology, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Biological & Environmental Science, The University of Helsinki, Helsinki, Finland; Department of Biology, American University of Beirut, Beirut, Lebanon; Department of Molecular Cell Function, Kumamoto University, Kumamoto, Japan; Roche, Basel CH-4070, Switzerland; University of New Mexico Cancer Center; Division of Molecular Medicine, and Divisions of Hematology and Medical Oncology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131.
منابع مشابه
Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens.
PURPOSE The IL11 receptor (IL11R) is an established molecular target in primary tumors of bone, such as osteosarcoma, and in secondary bone metastases from solid tumors, such as prostate cancer. However, its potential role in management of hematopoietic malignancies has not yet been determined. Here, we evaluated the IL11R as a candidate therapeutic target in human leukemia and lymphoma. EXPE...
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